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Balancing the 5 Levers of Autoimmune Disease: A Naturopathic Approach

Written by Portland Clinic of Natural Health on March 28, 2023


Autoimmune diseases are complex and multifaceted, affecting millions of people worldwide. These conditions occur when the body's immune system mistakenly attacks its own tissues, leading to chronic inflammation and damage. While the exact cause(s) of autoimmune diseases are multifactorial and may remain unknown, to some degree, a combination of genetic and environmental factors contribute to their development. From an evidence-based, naturopathic perspective, there are five primary levers that can influence the development and progression of autoimmune diseases. By understanding and addressing these levers, we can create personalized treatment plans to help manage symptoms and restore balance in the body.

Common Autoimmune Diseases:

Autoimmune diseases encompass a wide range of conditions, each affecting different organs and systems within the body. While some are relatively rare, others are more prevalent and well-known. Some of the most common autoimmune diseases include:

  1. Rheumatoid arthritis (RA): A chronic inflammatory disorder affecting the joints, leading to pain, swelling, and eventual joint damage.
  2. Systemic lupus erythematosus (SLE): A complex autoimmune disease that can impact multiple organ systems, including the skin, joints, kidneys, heart, and brain.
  3. Multiple sclerosis (MS): A neurological autoimmune disorder in which the immune system attacks the protective covering of nerve fibers, disrupting the communication between the brain and the rest of the body.
  4. Inflammatory bowel disease (IBD): A group of autoimmune conditions, including Crohn's disease and ulcerative colitis, that cause chronic inflammation in the digestive tract.
  5. Type 1 diabetes: An autoimmune disease in which the immune system attacks and destroys insulin-producing cells in the pancreas, leading to high blood sugar levels and the need for insulin replacement therapy.
  6. Psoriasis: A chronic skin condition caused by an overactive immune system, resulting in the rapid build-up of skin cells and the formation of red, scaly patches on the skin.
  7. Hashimoto's thyroiditis: An autoimmune disorder that causes the immune system to attack the thyroid gland, leading to chronic inflammation and reduced thyroid function, also known as hypothyroidism.
  8. Sjogren's syndrome: An autoimmune disease that targets the glands responsible for producing saliva and tears, resulting in dry mouth and dry eyes.
  9. Celiac disease: A digestive disorder triggered by the consumption of gluten, a protein found in wheat, barley, and rye, which leads to an immune response that damages the lining of the small intestine.

These are just a few examples of the many autoimmune diseases that affect millions of people worldwide. By understanding and addressing the five primary levers of autoimmune disease, we can create personalized treatment plans to help manage symptoms and restore balance in the body.

  1. Nutrition:

Food is the foundation of a healthy body, and it plays a crucial role in the development and management of autoimmune diseases. A nutrient-dense, anti-inflammatory diet can help reduce inflammation, support the immune system, and promote overall health. Focus on consuming whole, unprocessed foods rich in antioxidants, fiber, and healthy fats. Eliminate common food allergens and inflammatory triggers, such as gluten, dairy, and refined sugars. Incorporating personalized nutrition plans based on individual food sensitivities can further optimize health outcomes. (1)

  1. Gut Health:

A growing body of research highlights the critical role of gut health in the development of autoimmune diseases. The gut microbiome, the collection of microorganisms living in our intestines, has a significant impact on immune function. Imbalances in the gut microbiome, known as dysbiosis, can contribute to chronic inflammation and autoimmunity. Supporting gut health through probiotic supplementation, prebiotic-rich foods, and stress reduction can help maintain a balanced microbiome and promote immune system regulation. (2)

  1. Stress Management:

Chronic stress is a significant contributor to the development and progression of autoimmune diseases. Stress hormones, such as cortisol, can weaken the immune system and exacerbate inflammation. Incorporating stress management techniques, like mindfulness meditation, deep breathing exercises, and yoga, can help reduce stress levels and improve overall well-being. Establishing a strong support network and seeking professional counseling can further enhance mental and emotional resilience. (3)

  1. Sleep:

Quality sleep is essential for optimal immune function and overall health. Sleep deprivation can lead to increased inflammation and exacerbate autoimmune symptoms. Prioritize good sleep hygiene by establishing a regular sleep schedule, creating a calming bedtime routine, and optimizing your sleep environment. If you struggle with sleep disorders, seek professional guidance to address the underlying causes and develop tailored sleep strategies. (4)

  1. Detoxification:

Toxins from the environment, such as heavy metals, pesticides, and air pollutants, can contribute to inflammation and autoimmunity. By supporting the body's natural detoxification pathways, we can reduce the toxic burden and help restore balance. Consider incorporating regular detox practices like infrared sauna therapy, lymphatic drainage massage, and consuming detoxifying foods. Additionally, focus on reducing exposure to environmental toxins by choosing organic produce, using natural cleaning products, and investing in air and water filtration systems. (5)


Managing autoimmune diseases requires a comprehensive and personalized approach that addresses the five key levers: nutrition, gut health, stress management, sleep, and detoxification. By adopting an evidence-based, naturopathic perspective, we can empower individuals to take control of their health, reduce symptoms, and improve their overall quality of life. Remember to consult with a healthcare professional before making significant changes to your lifestyle or introducing new therapies to ensure safety and efficacy.


  1. Mazzucca CB, Raineri D, Cappellano G, Chiocchetti A. How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done. Nutrients. 2021 Nov 5;13(11):3956. doi: 10.3390/nu13113956. PMID: 34836210; PMCID: PMC8620243.
  2. Xu H, Liu M, Cao J, Li X, Fan D, Xia Y, Lu X, Li J, Ju D, Zhao H. The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases. J Immunol Res. 2019 Oct 27;2019:7546047. doi: 10.1155/2019/7546047. PMID: 31772949; PMCID: PMC6854958.
  3. Stojanovich L, Marisavljevich D. Stress as a trigger of autoimmune disease. Autoimmun Rev. 2008 Jan;7(3):209-13. doi: 10.1016/j.autrev.2007.11.007. Epub 2007 Nov 29. PMID: 18190880.
  4. Zielinski MR, Systrom DM, Rose NR. Fatigue, Sleep, and Autoimmune and Related Disorders. Front Immunol. 2019 Aug 6;10:1827. doi: 10.3389/fimmu.2019.01827. PMID: 31447842; PMCID: PMC6691096.
  5. Tsoukalas D, Fragoulakis V, Papakonstantinou E, Antonaki M, Vozikis A, Tsatsakis A, Buga AM, Mitroi M, Calina D. Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids. Metabolites. 2020 Dec 8;10(12):502. doi: 10.3390/metabo10120502. PMID: 33302528; PMCID: PMC7764183.

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