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Casein and Myelin Associated Glycoprotein: The Cross-Reactivity Connection

Written by Portland Clinic of Natural Health on September 11, 2023

In recent years, there's been increasing interest in the concept of dietary proteins and their potential cross-reactivity with the human body's proteins. One such topic of intrigue is the possible cross-reactivity between casein, a protein found in dairy products, and myelin associated glycoprotein (MAG), a component of the nervous system. Let's delve into the evidence behind this phenomenon.

What is Cross-Reactivity?

Before diving into the specifics, it's essential to understand the concept of cross-reactivity. At its core, cross-reactivity refers to the ability of an antibody, produced in response to one antigen, to also recognize and bind to a different antigen due to structural similarities. In the context of food proteins and autoimmunity, it suggests that consuming specific foods might lead to an immune response that mistakenly targets our own tissues. (1)

The Evidence: Casein and MAG

Some studies have looked at the relationship between dietary proteins and autoimmune responses, particularly within the context of multiple sclerosis (MS). MS is a chronic autoimmune disorder where the immune system attacks the myelin sheath, the protective layer covering nerve fibers. (2)

The hypothesis is that, after consuming casein, the body produces antibodies to neutralize it. Due to the structural similarities between casein and MAG, these antibodies might also bind to MAG, leading to an inflammatory response in the nervous system. (3)

However, it's essential to note that the evidence is not entirely conclusive. While some studies and clinical observations support the idea of cross-reactivity between casein and MAG, others don't find a strong connection. Factors like individual genetic predisposition, gut health, and the presence of other triggering agents can also influence the onset and progression of autoimmune conditions.

Implications and Recommendations

Given the potential link, some holistic and other healthcare professionals recommend a dairy-free diet, especially for individuals with MS or those at risk. However, it's crucial to approach this recommendation with caution. A blanket dietary restriction may not be suitable for everyone, and the potential benefits of removing dairy need to be weighed against the nutritional implications.

If you suspect a sensitivity to dairy or are concerned about its potential effects on your neurological health, consult with a holistic healthcare professional who works with autoimmune disease. They can provide personalized advice based on your health profile and the latest scientific evidence.

The potential cross-reactivity between casein and MAG is a topic of ongoing research. While some evidence suggests a link between dairy consumption and increased risk of autoimmune reactions, the connection is not definitive. As with many aspects of nutrition and health, individual factors play a significant role, and it's essential to make informed decisions based on a comprehensive understanding of the evidence.


  1. Trier NH, Houen G. Antibody Cross-Reactivity in Auto-Immune Diseases. Int J Mol Sci. 2023 Sep 2;24(17):13609. doi: 10.3390/ijms241713609. PMID: 37686415; PMCID: PMC10487534.
  2. Chunder R, Weier A, Mäurer H, Luber N, Enders M, Luber G, Heider T, Spitzer A, Tacke S, Becker-Gotot J, Kurts C, Iyer R, Ho PP, Robinson WH, Lanz TV, Kuerten S. Antibody cross-reactivity between casein and myelin-associated glycoprotein results in central nervous system demyelination. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2117034119. doi: 10.1073/pnas.2117034119. Epub 2022 Mar 2. PMID: 35235454; PMCID: PMC8916005.
  3. Chunder R, Heider T, Kuerten S. The prevalence of IgG antibodies against milk and milk antigens in patients with multiple sclerosis. Front Immunol. 2023 Jul 10;14:1202006. doi: 10.3389/fimmu.2023.1202006. PMID: 37492579; PMCID: PMC10364054.

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