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The Power of Epigenetic Testing for SNPs: A Naturopathic and Functional Medicine Perspective

Written by Portland Clinic of Natural Health on September 6, 2023

Epigenetics, a term coined from the Greek word 'epi' meaning 'on top of', refers to the modifications in gene expression without changes in the DNA sequence itself. While the DNA sequence or genetic code remains the same, epigenetic changes determine whether specific genes are turned 'on' or 'off'. This intricate interplay between genes and the environment paves the way for a unique field of health study, particularly from the perspective of naturopathic and functional medicine.

One specific area of epigenetic study that has gained attention is the testing for Single Nucleotide Polymorphisms (SNPs). SNPs are variations at a single position in a DNA sequence among individuals. They are akin to tiny switches that can alter the way our body responds to certain environmental factors, potentially leading to a plethora of health concerns. (1)

The Power of SNP Testing

Personalized Medicine

Naturopathic and functional medicine often emphasize individualized treatment plans. By understanding one's genetic susceptibilities through SNP testing, practitioners can tailor recommendations to one's unique genetic makeup.


Some SNPs have been associated with a higher risk of certain diseases. By identifying these SNPs early on, proactive measures can be undertaken to possibly prevent or delay the onset of diseases.

Dietary and Lifestyle Recommendations

Certain SNPs can influence how we metabolize nutrients or respond to specific dietary components. By understanding these, practitioners can provide precise dietary and lifestyle guidelines, thus enhancing therapeutic outcomes.

Optimized Supplementation

With SNP testing, one can understand specific nutrient needs or deficiencies. This knowledge allows for a more targeted approach to supplementation, avoiding potential over-supplementation or identifying crucial deficiencies.

Evidence Supporting Epigenetic Testing for SNPs

MTHFR gene polymorphism

One of the most studied SNPs is found in the MTHFR gene. Individuals with this polymorphism might have difficulties converting dietary folate into its active form, leading to potential cardiovascular and neurological concerns. By identifying this SNP, practitioners can recommend specific forms of folate supplementation or dietary changes. (2)

APOE gene polymorphism

APOE gene variations are linked with altered cholesterol metabolism and a higher risk of Alzheimer's disease. Identifying this can help with early preventive strategies. (3)

A Naturopathic and Functional Medicine Perspective

In the world of naturopathic and functional medicine, the goal is to understand the root cause of health concerns rather than just addressing the symptoms. Epigenetic testing for SNPs aligns perfectly with this philosophy. By diving deep into the unique genetic predispositions of an individual, practitioners can potentially unravel the underlying contributors to health challenges.

While epigenetic testing is an immensely powerful tool, it's essential to remember that genes are not destiny. They offer a predisposition, but our environment, lifestyle, diet, and mindset play pivotal roles in determining health outcomes. SNP testing is just one piece of the intricate puzzle of health.

As the realm of genetics continues to evolve, so does its potential to transform healthcare. SNP testing from an epigenetic standpoint offers a promising avenue, especially for practitioners who see patients as unique individuals, aiming to offer comprehensive, personalized care.


  1. Kanherkar RR, Stair SE, Bhatia-Dey N, Mills PJ, Chopra D, Csoka AB. Epigenetic Mechanisms of Integrative Medicine. Evid Based Complement Alternat Med. 2017;2017:4365429. doi: 10.1155/2017/4365429. Epub 2017 Feb 21. PMID: 28316635; PMCID: PMC5339524.
  2. Cortese C, Motti C. MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr. 2001 Apr;4(2B):493-7. doi: 10.1079/phn2001159. PMID: 11683544.
  3. Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nat Rev Neurol. 2019 Sep;15(9):501-518. doi: 10.1038/s41582-019-0228-7. Epub 2019 Jul 31. PMID: 31367008; PMCID: PMC7055192.

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